TECHNOZYM® ADAMTS-13 Activity ELISA
Freeze-dried
Packaging options
| 4-5450701 | Kit | 12 x 8 tests |
Determination of ADAMTS-13 activity in colorimetry
Description of the TECHNOZYM® ADAMTS-13 Activity ELISA
TECHNOZYM® ADAMTS-13 Activity ELISA is a chromogenic test for the determination of ADAMTS-13 activity in human plasma by ELISA method at 450nm.
Informations
ADAMTS13 (a disintegrin-like and metalloproteinase with thrombospondin type 1 motif 13) is an enzyme (VWFcleaving protease or VWF-CP) that specifically cleaves von Willebrand factor (VWF), which induce platelet thrombus formation under high shear stress.
If the activity of ADAMTS13 is lowered for some reason, however, unusually large VWF multimers may accumulate, causing thrombosis due to platelet aggregation, which in turn may lead to TMA (thrombotic microangiopathy) such as TTP (thrombotic thrombocytopenic purpura).
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