Mouse Factor X

Molecular weight (Da) : 58 900
Extinction coef. : 11.6
Isoelectric point: 4.9-5.2
Structure: 2 subunits (16 200 & 42 000), N-terminal Gla domain and 2 EGF domains.

A proenzyme or zymogen is a protein precursor of an enzyme which can give, after activation, an active enzyme. Factor X (FX) is a glycoprotein synthesized by the liver, dependent on vitamin K. FX is involved in the common pathway of coagulation. It is activated in FXa by the FT-FVIIa complex or by the FVIIIa-FIXa complex in the presence of phospholipids. FXa is neutralized by TFPI and antithrombin.