Bovine Lactadherin

MW(Da) : 47 000
Extinction coef. : 16,5
Structure : single chain with 2 EGF domains and 2 C domains.
Lactadherin is purified from unpasteurized bovine milk.

The vast majority of plasma derivatives is pure (without additives) with > 95 % purity SDS-PAGE. Expiration date of one year from delivery. Delivery in large quantities. Discount according to quantities.

Lactadherin is a glycoprotein secreted by the mammary glands. It is involved in the recognition of apoptotic cells by macrophages, it has sequence homology with an angiogenic protein Del-1 and has an RGD sequence allowing it to bind to certain integrins. It binds the phophastidyl-L-serines independently of calcium via the C2 domain playing an anticoagulant role and the integrins via the EGF domain.