Human antithrombin

Inactivates several serine proteinases
Activity : 0.7 to 1.0 mole thrombin / mole AT
MW(Da) : 58 000
Extinction coef. : 14.5
Isoelectric point: 4.9-5.3
Structure: single chain, 3 intrachain disulfide bonds, 10% alpha-helise, 30-40% structure-beta, 50% random coil, scissile bond (Arg 385-Ser 386)

Supplied lyophilized or frozen.
Expiry date > 1 year.
Glass vial or plastic tubes.
Discount according to quantities.

 

Antithrombin is a glycoprotein of the serpin family, synthesized by the liver with a half-life of 3 days. It is the most potent of the physiological inhibitors of coagulation. It mainly inhibits thrombin but also at a lower level FIXa, FXa, FXIa. Its inhibitory action is amplified in the presence of heparin or heparan sulfate.