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IMUBIND® PAI-2 ELISA

Freeze-dried
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26-ADG823Kit96 tests

The IMUBIND® PAI-2 ELISA is an enzyme-linked immunoassay for the determination of human PAI-2 in human biological fluids. This assay is for research use only. It is not intended for diagnostic or therapeutic procedures.

Description of the IMUBIND® PAI-2 ELISA

This assay detects the low molecular weight (48 kD) and the high molecular weight glycosylated (60 kD) form of PAI-2.

Advantages

Free PAI-2 and PAI-2/uPA and PAI-2/tPA complexes are recognized. The assay is insensitive to PAI-1.

Informations

Plasminogen activator inhibitor 2 (PAI-2) or SERPINB2 belongs to the serine protease inhibitor superfamily. It has 2 forms; a secreted form of 60kDa and an intracellular form of 47kDa. It effectively inhibits double-stranded t-PA and u-PA but weakly inhibits single-stranded t-PA. PAI-2 is present in the plasma of pregnant women, gingival fluid, monocytes and macrophages, and keratinocytes.

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