Pefakit® APC-R Factor V Leiden Controls
Freeze-dried
Packaging options
| 8-502-21 | Kit | 2 x 3 x 1.0 mL |
Control plasmas used to confirm the Factor V Leiden mutation (FV: Q506) in tests to determine the functional phenotype of resistance to activated protein C.
Description of the Pefakit® APC-R Factor V Leiden Controls
Advantages
Results available on different types of analyzers.
Informations
The mutated FV is referred to as FV Leiden. This mutation leads to the replacement at position 506 of an arginine by a glutamine (Arg506Gln), which affects one of the sites of cleavage of FV by PCa. As a result, FV "resists" inactivation by PCa. This factor V loses its function as a cofactor of the protein C system, that is to say of a system which inhibits coagulation; on the other hand, it retains its procoagulant properties. There are other cases of mutations related to the resistance of activated protein C.
product sheet
