Human prothrombin
| 9-HCP-0010 | Vial | 2 mg |
| 9-HCP-0010-1 | Vial | 1 mg |
Structure : 1 N-terminal Gla domain, 2 kringles domains and a protease domain.
Origin : Human Blood / Plasma
Formulation : 50 % Glycerol / H₂O (v/v)
Description of the Human prothrombin
MW(Da) : 72 000
Extinction coef. : 13.8
Isoelectric point : 4.7-4.9
Advantages
The vast majority of zymogens is pure (without additives) with > 95 % purity SDS-PAGE.
No additive or preservative.
Informations
A zymogen (or proenzyme) is an inactive enzyme precursor. A zymogen requires a biochemical change for it to become an active enzyme. A proenzyme or zymogen is a protein precursor of an enzyme which can give, after activation, an active enzyme. Factor II (FII) or prothrombin is a glycoprotein synthesized by the liver, zymogen of a serine protease. It is a vitamin K-dependent clotting factor. Its half-life is 50 to 120 hours. FII is activated by the prothrombinase thrombin complex which plays a central role in the coagulation process. It will transform fibrinogen into fibrin, amplify its own formation and activate the protein C, TAFI and platelet systems. There are constitutional deficits in FII which are very rare and acquired deficits which can be observed during antivitamin K treatment or deficiency in vitamin K, CIVD, anti-FII autoantibodies.
