Purified vitronectin
Freeze-dried
Packaging options
| 4-TC41140 | Vial | 50 µg |
Formulation : 0.02M potassium phosphate buffer, 0.1M NaCl, pH 7.4
Description of the Purified vitronectin
MW(Da) : 55 000 to 72 000
From human plasma
Informations
Vitronectin (Vn) is an adhesive glycoprotein, synthesized by the liver, released in plasma and present in the extracellular matrix. Vn binds PAI-1. This complex fully activates PAI-1, unlike PAI-1 in solution, where it does not appear to be stable and inactive. Vn therefore seems to regulate the enzymatic specificity of PAI-1, by stabilizing it. Decreased Vn levels occur in DICs and liver disease (cirrhosis). Vn deposition is associated with atherosclerotic lesions.
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