Murine monoclonal antibody anti-gamma-carboxyglutamyl (Gla) residues
| 11-3570 | Vial | 0.5 mg |
The product is a murine lgG 2bK monoclonal antibody purified from mouse ascites fluid via Protein G affinity chromatography. A synthesized eight-
branched immunogenic complex was used as the immunizing antigen
Description of the Murine monoclonal antibody anti-gamma-carboxyglutamyl (Gla) residues
This product is directed against γ-carboxyglutamyl(Gla) residues found in various coagulation proteins of human and other species and venoms. lt reacts with the Gla domains found in human prothrombin, prothrombin fragment 1, factor VII, recombinant factor VIIa, factor IX, factor X, Protein C, Protein S and bovine bone Gla protein. Ca2+ (5 mM concentration) strongly inhibits the binding of this product to human prothrombin in a non-competitive immunofluorescence assay
Advantages
The lyophilized presentation allows greater stability until the expiration date.
Informations
Gamma-Carboxyglutamic Acid is an amino acid derived from glutamate in a reaction that involves vitamin K. There are many Gla residues of coagulation proteins. Gla residues are ligands for Ca2 + ions, a critical reaction for the activity of coagulation factors and proteins.
