APC Resistance Kit

The APC Resistance Kit is a functional plasma coagulation test that differs from other functional tests for resistance to APC by acting specifically at the prothrombinase complex.
It is based on an FV-dependent prothrombin activator isolated from snake venom.
The strength and specificity of the test are improved by eliminating possible disturbances by factors upstream of the coagulation cascade and calcium independence.

- Vials suitable for hemostasis analyzers
- Protocols are available on request
- Excellent stability on board hemostasis analyzers
- Excellent linearity over a large measurement area

Resistance to activated protein C is an anomaly described by Dahlbäck in 1993.
Bertina discovered in 1994 the presence of a mutation in the factor V (FV) gene.
This mutation leads to the replacement at position 506 of an arginine by a glutamine (Arg506Gln), which affects one of the sites of cleavage of FV by PCa. As a result, FV "resists" inactivation by PCa.
The mutated FV is referred to as FV Leiden. This factor V loses its function as a cofactor of the protein C system, that is to say of a system which inhibits coagulation; on the other hand, it retains its procoagulant properties. There are other cases of mutations related to the resistance of activated protein C.