TECHNOZYM® ADAMTS-13 INH ELISA
| 4-5450401 | Kit | 12 x 8 tests |
| 4-5450451 | Kit | 6 x 8 tests |
Determination of ADAMTS-13 inhibitors by colorimetry
Description of the TECHNOZYM® ADAMTS-13 INH ELISA
TECHNOZYM® ADAMTS-13 INH ELISA is a chromogenic test for the detection in plasma or serum of human autoantibodies directed against ADAMTS-13 by ELISA method at 450nm.
Informations
This protease has the role of regulating the size of abnormally large multimers of von Willebrand factor.
The presence of anti-ADAMTS-13 autoantibodies inhibits the cleavage activity of this enzyme, causing accumulation of high molecular weight VWF multimer in plasma.
These autoantibodies are considered to be the main cause of PTT (Thrombotic Thrombocytopenic Purpura). TECHNOZYM® ADAMTS-13 INH helps monitor the effectiveness of plasma exchange therapy, and differentiate the congenital and acquired form of the disease when combined with an ADAMTS-13 activity test.
